Title:
3-desoxy-2-methylene 19- Noll - vitamin D similar objects and those use
Document Type and Number:
Japanese Patent JP6035331
Kind Code:
B2
Abstract:
This invention discloses 3-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D3 and (20R)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D3 as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to monocytes thus evidencing use as anti-cancer agents especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also exhibit relatively high calcemic activity evidencing use in the treatment of bone diseases.
Inventors:
Deluca Hector F.
Plum Lori. A.
Shishinski Rafar Earl.
Sibirska Isabella
Clarget-Dame Margaret
Plum Lori. A.
Shishinski Rafar Earl.
Sibirska Isabella
Clarget-Dame Margaret
Application Number:
JP2014515955A
Publication Date:
November 30, 2016
Filing Date:
June 13, 2012
Export Citation:
Assignee:
Wisconsin Alumni Research Foundation
International Classes:
C07C401/00; A61K31/593; A61P19/08; A61P19/10; A61P35/00; A61P35/02; C07F7/18
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Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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