Title:
【発明の名称】自己免疫疾患を治療するための3-メチレンステロイド誘導体
Document Type and Number:
Japanese Patent JP2003517472
Kind Code:
A
Abstract:
The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R1 is H or together with R3 forms a beta-epoxide or R1 is absent if there is a 5-10 or 4-5 double bond; R2 is (C1-C5) alkyl or CF3; R3 is betaH, betaCH3 or together with R1 forms a beta-epoxide or R3 is absent if there is a 5-10 double bond; R4 is H, lower alkyl; Y is [H, H], [OH, H], =O, [OH, lower alkyl], [OH, (C2-C5)alkenyl], [OH, (C2-C5)alkynyl] or (C1-C6) alkylidene, whereby said alkyl, alkenyl, alkynyl and alkylidene is optionally halogenated; =NOR5, whereby R5 is H, lower alkyl; dotted lines represent an optional double bond, or prodrugs thereof for the treatment of arthritic diseases and/or autoimmune diseases.
Inventors:
Plate, ralph
Bergcas, Uhelmina Maria
Bergcas, Uhelmina Maria
Application Number:
JP2001541008A
Publication Date:
May 27, 2003
Filing Date:
November 23, 2000
Export Citation:
Assignee:
Akzo Novel N B
International Classes:
A61K31/565; A61K31/56; A61K31/569; A61K31/575; A61P19/02; A61P29/00; A61P37/02; C07J1/00; C07J3/00; C07J5/00; C07J9/00; C07J41/00; C07J51/00; C07J71/00; (IPC1-7): C07J1/00; A61K31/565; A61K31/569; A61K31/575; A61P19/02; A61P29/00; A61P37/02; C07J3/00; C07J9/00
Domestic Patent References:
| JPS6212796A | 1987-01-21 |
Foreign References:
| EP0159739A1 | 1985-10-30 | |||
| US1171221A | 1916-02-08 | |||
| EP0389035A1 | 1990-09-26 | |||
| GB2175905A | 1986-12-10 | |||
| US1085035A | 1914-01-20 | |||
| US3301880A | 1967-01-31 |
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)