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Patent Searching and Data


Title:
3-PIPERAZINOSYDNONE IMINE, ITS PREPARATION AND APPLICATION METHOD
Document Type and Number:
Japanese Patent JPH04273873
Kind Code:
A
Abstract:

PURPOSE: To provide a new 3-aminosydnone imine and its acid addition salt useful a antihypertensive drugs for prophylactic treatment of angina pectoris for hypertension, which have ability to maintain strong action for many hours.

CONSTITUTION: The compound of formula I [R1 is a 1-4C alkyl or di-(1-4C) alkylamino, etc.; R2 is H or COR3 (R3 is a 1-4C alkyl, 1-4C alkoxy, etc.)], e.g. 3-(2,2-dimethyl-4-methanesulfonyl-piperazin-1-yl)-sydnone imine-hydorchloride, is prepared by the cyclization of a compound of formula II using a reagent for cyclization in an organic- or an inorganic solvent, or dispersing agent or diluting reagent at -10 to 40°C, esp. 0 to 40°C, pref. 0 to 20°C. The compound such that the pH value of its aqueous solution shows below 3, is used as a reagent for cyclization.


Inventors:
Schoenafinger, Karl
Bohn, Helmut
Just, Melitta
Application Number:
JP1991000256736
Publication Date:
September 30, 1992
Filing Date:
October 03, 1991
Export Citation:
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Assignee:
CASSELLA AG
International Classes:
A61K31/495; A61P9/00; C07D271/04; C07D413/04; C07D413/12; (IPC1-7): A61K31/495; C07D413/04