Title:
3,4-ジヒドロベンゾオキサジン化合物及びバニロイド受容体1型(VR1)活性阻害剤
Document Type and Number:
Japanese Patent JP4086895
Kind Code:
B2
Abstract:
A 3,4-dihydrobenzoxazine compound of the present invention is represented by the following formula [1] (wherein X is a nitrogen atom or CR 3 ; R 1 is a hydrogen atom or a halogen atom; R 2 is a C1-6 alkoxy group which may be substituted with the same or different 1 to 5 substituents selected from a halogen atom and a hydroxyl group; and R 3 is a halogen atom. However, R 1 is a halogen atom when X is CR 3 ). This compound is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, etc.
Inventors:
Yoshihisa Koga
Shinji Yada
Takayuki Yamazaki
Tatsuya Matsumoto
Masahiro Sakata
Wataru Kondo
Yoshikazu Hori
Shinji Yada
Takayuki Yamazaki
Tatsuya Matsumoto
Masahiro Sakata
Wataru Kondo
Yoshikazu Hori
Application Number:
JP2007552030A
Publication Date:
May 14, 2008
Filing Date:
December 22, 2006
Export Citation:
Assignee:
Japan Tobacco Inc.
International Classes:
C07D413/04; A61K31/538; A61K45/00; A61P1/04; A61P3/10; A61P9/10; A61P13/02; A61P13/10; A61P17/00; A61P17/02; A61P17/04; A61P19/02; A61P25/00; A61P25/04; A61P25/06; A61P27/16; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07D413/14
Domestic Patent References:
| JP2005516951A | ||||
| JP2005518371A |
Foreign References:
| WO2005103018A1 | ||||
| WO2005077938A1 | ||||
| WO2005077944A1 | ||||
| WO2005023807A2 |
Attorney, Agent or Firm:
Teruo Daito