Title:
3,5-DIHYDROXYHEPTANOIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP3168728
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject new compound, having inhibiting action on hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductases, cholesterol lowering action and suppressing action on the production of peroxylipids and useful as a therapeutic agent for arteriosclerosis.
CONSTITUTION: The objective compound expressed by formula I [R1 is H, nitro, N(R4)R5 (R4 and R5 are H, lower alkyl, aryl, acyl, thiocarbamoyl, etc.); R2 and R3 are H or lower alkyl], e.g. trans(±)-6-[2,3-dihydro-2,2,4,6-tetramethyl-5- nitrobenzo[b]furan-7-yl]ethyl-4-hydroxytetrahydrofuran-2-one. This compound expressed by formula I is obtained by nitrating a benzofuran derivative expressed by formula II (R is formula III, etc.).
Inventors:
Masakatsu Matsumoto
Nobuko Watanabe
Hideko Mori
Tetsuaki Yamaura
Aoyama Misao
Nobuko Watanabe
Hideko Mori
Tetsuaki Yamaura
Aoyama Misao
Application Number:
JP27499692A
Publication Date:
May 21, 2001
Filing Date:
September 18, 1992
Export Citation:
Assignee:
Fujirebio Co., Ltd.
International Classes:
A61K31/34; A61K31/343; A61K31/35; A61K31/351; A61P3/02; A61P3/06; A61P9/10; A61P43/00; C07D307/79; C07D407/06; (IPC1-7): C07D307/79; C07D407/06