Title:
3,7-DISUBSTITUTED-2 OR 3-CEPHEM-4-CARBOXYLIC ACID COMPOUND OR ITS SALT, THEIR PREPARATION, AND PREVENTIVES AND REMEDIES FOR MICROBISM COMPRISING THEM AS ACTIVE CONSTITUENTS
Document Type and Number:
Japanese Patent JPS5559195
Kind Code:
A
Abstract:
NEW MATERIAL:The title compound (or salt) of formula I [R1 is (substituted) amino group: R2 is carboxyl group, etc.; formula III is di(lower) alkylamino (lower) alkylamino, N-containing heterocyclic (lower)alkyl amino, hydroxypiperidino group, etc.; X is sulfur or sulfoxide].
EXAMPLE: 7-[ 2-Mthoxyimino-2-( 2-formamidothiazol-4-yl )acetamido ]-3-( 1-imidazolyl)carbonyloxymethyl-3-cephem-4-carboxylic acid benzhydryl(syn-isomer).
USE: Preventives and remedies for microbism.
PROCESS: A hydroxymethyl derivative of formula II is reacted with N,N'-carbonyldiimidazole to give the compound of formula Ia.
Inventors:
UEDA IKUO
KOBAYASHI MASAKAZU
YAMADA CHIYOUJI
ONO HIROKI
KOBAYASHI MASAKAZU
YAMADA CHIYOUJI
ONO HIROKI
Application Number:
JP13682479A
Publication Date:
May 02, 1980
Filing Date:
October 22, 1979
Export Citation:
Assignee:
FUJISAWA PHARMACEUTICAL CO
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D501/14; C07D501/18; C07D501/20; C07D501/26; C07D501/28; C07D501/30; C07D501/34; C07D501/38; C07D501/60; (IPC1-7): A61K31/545; C07D501/14; C07D501/18; C07D501/26
Domestic Patent References:
| JPS5278891A | 1977-07-02 | |||
| JPS52125188A | 1977-10-20 | |||
| JPS52102294A | 1977-08-27 |