Title:
MANUFACTURING METHOD OF (3R,4S)-1-(4-FLUOROPHENYL)-[3(S)-HYDROXY-3-(4-FLUOROPHENYL)PROPYL]-[4-(PHENYLMETHOXY)PHENYL]-2-AZETIDINONE
Document Type and Number:
Japanese Patent JP2017002008
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for effectively manufacturing high purity (3R,4S)-1-(4-fluorophenyl)-[3(S)-hydroxy-3-(4-fluorophenyl)propyl]-[4-(phenylmethoxy)phenyl]-2-azetidinone with reduced contents of specific impurities and enantiomers.SOLUTION: When a benzyl protective body is manufactured by reacting a benzyl protective keto body and borane in presence of a CBS catalyst, the benzyl protective keto body is injected under a condition with co-existing a part of borane of needed amount in a reaction system in advance and remaining borane is added later to conduct the reaction.SELECTED DRAWING: None
Inventors:
SHIMIZU TOMOHIRO
Application Number:
JP2015120362A
Publication Date:
January 05, 2017
Filing Date:
June 15, 2015
Export Citation:
Assignee:
TOKUYAMA CORP
International Classes:
C07D205/08; A61K31/397; A61P3/06
Foreign References:
| WO2009067960A2 | 2009-06-04 | |||
| WO2010113182A1 | 2010-10-07 | |||
| WO2006137080A1 | 2006-12-28 |