Title:
４−（３−クロロ−２−フルオロアニリノ）−７−メトキシ−６−｛［１−（Ｎ−メチルカルバモイルメチル）ピペリジン−４−イル］オキシ｝キナゾリンのフマル酸塩
Document Type and Number:
Japanese Patent JP5739802
Kind Code:
B2
Abstract:
4-(3-chloro-2-fluoroanilino)-7 methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline difumarate, pharmaceutical compositions containing the difumarate, the use of the difumarate in the treatment of hyperproliferative disorders such as cancer and processes for the manufacture of the difumarate are described.
Inventors:
Boardman, Kay Allison
Hard, Susan Elizabeth
Dobson, Andrew Hornby
Whitlock, Bryan
Hard, Susan Elizabeth
Dobson, Andrew Hornby
Whitlock, Bryan
Application Number:
JP2011509008A
Publication Date:
June 24, 2015
Filing Date:
May 11, 2009
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07D401/12; A61K31/517; A61K47/12; A61K47/26; A61K47/32; A61K47/38; A61P35/00
Domestic Patent References:
| JP2007505875A | ||||
| JP2005529090A | ||||
| JP2007500177A |
Other References:
International Journal of Pharmaceutics,1986年,Vol.33,pp.201-217
Journal of Pharmaceutical Sciences,1977年,Vol.66, No.1,pp.1-19
Journal of Pharmaceutical Sciences,1977年,Vol.66, No.1,pp.1-19
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Toshitaka Tsurugi
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Toshitaka Tsurugi