Title:
４－ヒドロキシピペリジン誘導体およびユビキチン特異的プロテアーゼ１９（ＵＳＰ１９）の阻害剤としてのその使用
Document Type and Number:
Japanese Patent JP7464526
Kind Code:
B2
Abstract:
Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in reducing the loss of muscle mass.
Inventors:
James Samuel Shayne Roundtree
Stephen Christopher Whitehead
Adam Pyotr Trieder
Lauren Emma Proctor
Stephen David Shepherd
Frank barkamp
Juana Rita Castro Costa
Colin O'Daud
Timothy Harrison
Stephen Christopher Whitehead
Adam Pyotr Trieder
Lauren Emma Proctor
Stephen David Shepherd
Frank barkamp
Juana Rita Castro Costa
Colin O'Daud
Timothy Harrison
Application Number:
JP2020541791A
Publication Date:
April 09, 2024
Filing Date:
January 31, 2019
Export Citation:
Assignee:
Almac Discovery Limited
International Classes:
C07D211/78; A61K31/438; A61K31/444; A61K31/454; A61K31/4545; A61K31/4725; A61K31/496; A61K31/497; A61K31/4985; A61K31/506; A61K31/517; A61K31/519; A61K31/5377; A61K31/538; A61K31/5383; A61K31/5386; A61K31/541; A61K31/55; A61P3/04; A61P3/10; A61P21/00; A61P43/00; C07D401/06; C07D401/14; C07D405/14; C07D409/14; C07D413/06; C07D413/14; C07D417/14; C07D471/04; C07D487/04; C07D491/048; C07D491/107; C07D495/04
Domestic Patent References:
| JP2018500377A | ||||
| JP2018500376A | ||||
| JP2014527064A | ||||
| JP2000514821A |
Foreign References:
| WO2017212012A1 | ||||
| WO2017212010A1 | ||||
| WO2016126935A1 | ||||
| WO2016126929A1 | ||||
| WO2016126926A1 |
Other References:
GERALD GAVORY; ET AL,DISCOVERY AND CHARACTERIZATION OF HIGHLY POTENT AND SELECTIVE ALLOSTERIC USP7 INHIBITORS,NATURE CHEMICAL BIOLOGY,2017年12月04日,VOL:14, NR:2,,PAGE(S):118 - 125(1-40, 1-30, 1-21),http://dx.doi.org/10.1038/nchembio.2528
ANDREW P TURNBULL; ET AL,MOLECULAR BASIS OF USP7 INHIBITION BY SELECTIVE SMALL-MOLECULE INHIBITORS,NATURE,2017年10月18日,VOL:550, NR:7677,,PAGE(S):481 - 486,http://dx.doi.org/10.1038/nature24451
Database REGISTRY,2017年,RN 2127242-00-4, RN 2125660-99-1, RN 2127012-06-8, RN 1263281-24-8, RN 2127012-74-0, Retrieved from STN international [online] ;retrieved on 1 January 2023
ANDREW P TURNBULL; ET AL,MOLECULAR BASIS OF USP7 INHIBITION BY SELECTIVE SMALL-MOLECULE INHIBITORS,NATURE,2017年10月18日,VOL:550, NR:7677,,PAGE(S):481 - 486,http://dx.doi.org/10.1038/nature24451
Database REGISTRY,2017年,RN 2127242-00-4, RN 2125660-99-1, RN 2127012-06-8, RN 1263281-24-8, RN 2127012-74-0, Retrieved from STN international [online] ;retrieved on 1 January 2023
Attorney, Agent or Firm:
Michiko Matsutani
Sei Morimoto
Nobuhiko Akiyama
Sei Morimoto
Nobuhiko Akiyama