Title:
4-(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDINONE DERIVATIVE AS PDE-4 INHIBITOR FOR TREATMENT OF NEUROLOGICAL SYNDROME
Document Type and Number:
Japanese Patent JP2009286797
Kind Code:
A
Abstract:
To provide a new compound selectively inhibiting PDE4 enzyme, improved in reduction of side effects and easily introduced into cells, particularly into nerve cells, to provide its production method, and to provide a method of treating a patient using the compound.
There are provided 4-(substituted-phenyl)-2-pyrrolidinone compounds achieving selective PDE4 inhibition. The compounds represented by chemical formula (I) exhibit improved PDE4 inhibition as compared to compounds like rolipram, and show selectivity with regard to inhibition of other classes of PDEs.
Inventors:
LIU RUIPING
DE VIVO MICHAEL
HESS HANS-JURGEN ERNST
HOPPER ALLEN
KUESTER ERIK
TEHIM ASHOK
DE VIVO MICHAEL
HESS HANS-JURGEN ERNST
HOPPER ALLEN
KUESTER ERIK
TEHIM ASHOK
Application Number:
JP2009205533A
Publication Date:
December 10, 2009
Filing Date:
September 07, 2009
Export Citation:
Assignee:
MEMORY PHARMACEUTICAL CORP
International Classes:
C07D207/267; A61K31/4015; A61K31/4025; A61K31/4439; A61P1/04; A61P3/04; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P11/08; A61P13/10; A61P13/12; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/14; A61P19/02; A61P19/08; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/16; A61P31/18; A61P35/02; A61P37/02; A61P37/08; A61P43/00; C07D207/26; C07D207/27; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12
Domestic Patent References:
| JPS5522686A | 1980-02-18 | |||
| JPH08501318A | 1996-02-13 | |||
| JPS62501289A | 1987-05-21 | |||
| JPH09502979A | 1997-03-25 | |||
| JPH07300455A | 1995-11-14 |
Foreign References:
| WO1992019594A1 | 1992-11-12 | |||
| US5128358A | 1992-07-07 |
Other References:
JPN6012045084; ＳＣＨＭＩＥＣＨＥＮ，Ｒ． ｅｔ ａｌ．: 'Ｃｌｏｓｅ ｃｏｒｒｅｌａｔｉｏｎ ｂｅｔｗｅｅｎ ｂｅｈａｖｉｏｒａｌ ｒｅｓｐｏｎｓｅ ａｎｄ ｂｉｎｄｉｎｇ ｉｎ ｖｉｖｏ ｆｏｒ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ ｒｏｌｉｐｒａｍ-ｓｅｎ' Ｐｓｙｃｈｏｐｈａｒｍａｃｏｌｏｇｙ（Ｂｅｒｌｉｎ， Ｇｅｒｍａｎｙ） Ｖｏｌ．１０２， Ｎｏ．１, 1990, ｐ．１７-２０
JPN6012045085; ＨＵＬＭＥ，Ｃ． ｅｔ ａｌ．: 'Ｑｕａｔｅｒｎａｒｙ ｓｕｂｓｔｉｔｕｔｅｄ ＰＤＥ ＩＶ ｉｎｈｉｂｉｔｏｒｓ． ＩＩ： ｔｈｅ ｓｙｎｔｈｅｓｉｓ ａｎｄ ｉｎ ｖｉｔｒｏ ｅｖａｌｕａｔｉｏｎ ｏｆ ａ ｎｏｖｅｌ ｓｅｒｉｅ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．８， Ｎｏ．４, 1998, ｐ．３９９-４０４
JPN6012045086; ＦＥＬＤＭＡＮ，Ｐ．Ｌ． ｅｔ ａｌ．: 'Ｐｈｏｓｐｈｏｄｉｅｓｔｅｒａｓｅ Ｔｙｐｅ ＩＶ Ｉｎｈｉｂｉｔｉｏｎ． Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐｓ ｏｆ １，３-Ｄｉｓｕｂｓｔｉｔｕｔｅｄ Ｐｙｒｒｏｌｉｄ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３８， Ｎｏ．９, 1995, ｐ．１５０５-１５１０
JPN6012045085; ＨＵＬＭＥ，Ｃ． ｅｔ ａｌ．: 'Ｑｕａｔｅｒｎａｒｙ ｓｕｂｓｔｉｔｕｔｅｄ ＰＤＥ ＩＶ ｉｎｈｉｂｉｔｏｒｓ． ＩＩ： ｔｈｅ ｓｙｎｔｈｅｓｉｓ ａｎｄ ｉｎ ｖｉｔｒｏ ｅｖａｌｕａｔｉｏｎ ｏｆ ａ ｎｏｖｅｌ ｓｅｒｉｅ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．８， Ｎｏ．４, 1998, ｐ．３９９-４０４
JPN6012045086; ＦＥＬＤＭＡＮ，Ｐ．Ｌ． ｅｔ ａｌ．: 'Ｐｈｏｓｐｈｏｄｉｅｓｔｅｒａｓｅ Ｔｙｐｅ ＩＶ Ｉｎｈｉｂｉｔｉｏｎ． Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐｓ ｏｆ １，３-Ｄｉｓｕｂｓｔｉｔｕｔｅｄ Ｐｙｒｒｏｌｉｄ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３８， Ｎｏ．９, 1995, ｐ．１５０５-１５１０
Attorney, Agent or Firm:
Kiyoaki Takita