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Title:
4-ARYLMETHYLENE-5-ALKENYLIDNE-2-CYCLOPENTENONE AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JPS6287547
Kind Code:
A
Abstract:

NEW MATERIAL:A compound shown by the formula I [R1 is 1W10C (substituted) phenyl; Ar is 6W12C (substituted)phenyl; wavy line is single bond and E-form or Z-form based on double bond or a mixture of them].

EXAMPLE: 4-p-Fluorophenylmethylene-5-(4, 7-dihydroxy-2-heptenylidene)-2-cyclo pentenone.

USE: A drug showing improved carcinostatic action, useful as a carcinostatic agent, expected as a compound showing antiviral action.

PREPARATION: A phenyl sulfide shown by the formula II is oxidized with an organic peracid such as m-chloroperbenzoic acid, etc., in a reaction medium such as methylene chloride, etc., at -78W0°C for 30minW2hr, then heated in an aromatic hydrocarbon such as toluene, etc., approximately at reflux tempera ture to eliminate PhSOH and deprotected when R1 contains protected OH or ester group, to give a compound shown by the formula I.


Inventors:
NOGAMI JUNZO
KUROZUMI SEIJI
Application Number:
JP22491985A
Publication Date:
April 22, 1987
Filing Date:
October 11, 1985
Export Citation:
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Assignee:
TEIJIN LTD
International Classes:
A61K31/12; A61K31/557; A61K31/5575; A61K31/695; A61P31/12; A61P35/00; C07C45/00; C07C67/00; C07C49/747; C07C69/157; C07C69/716; C07C69/738; C07C313/00; C07C319/20; C07C323/22; C07C323/62; C07C401/00; C07C405/00; C07D309/12; C07F7/18; (IPC1-7): A61K31/12; A61K31/557; C07C49/747; C07C69/716; C07C149/32; C07C177/00; C07F7/18
Attorney, Agent or Firm:
Maeda Junhiro