4-DEDIMETHYLAMINO TETRACYCLINE COMPOUNDS

Japanese Patent JP2015063557

A

PROBLEM TO BE SOLVED: To provide novel 4-dedimethylamino tetracycline compounds which can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.SOLUTION: The present invention provides substituted tetracycline compounds represented by the following formula, where X is CHor the like, R-R, R, R-Rare a hydrogen atom or the like, Ris 2-methoxy-5-dimethylaminomethyl phenoxy, a dimethylamino group or the like, and Ris a hydrogen atom, a t-butyl group, a 4-carboxyphenyl group or the like.

NELSON MARK L
OHEMENG KWASI

JP2014260626A

April 09, 2015

December 24, 2014

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PARATEK PHARM INNC

C07C237/26; A61K31/137; C07D295/14; A61K31/16; A61K31/18; A61K31/195; A61K31/275; A61K31/341; A61K31/36; A61K31/381; A61K31/40; A61K31/4035; A61K31/426; A61K31/4402; A61K31/4453; A61K31/5375; A61P9/00; A61P11/00; A61P25/00; A61P31/04; A61P35/00; A61P43/00; C07C235/40; C07C235/70; C07C251/48; C07C255/41; C07C255/43; C07C271/22; C07C271/54; C07C271/58; C07C275/42; C07C275/54; C07C279/18; C07C311/06; C07C311/08; C07C333/08; C07C335/22; C07C381/10; C07D209/48; C07D213/56; C07D277/20; C07D277/42; C07D295/155; C07D295/185; C07D307/54; C07D317/60; C07D333/60; C07F7/08; C07F9/24; C07F9/40

WO2001087823A1	2001-11-22
WO2000028983A1	2000-05-25
WO2000018353A2	2000-04-06
WO2002004407A2	2002-01-17
WO2002004406A2	2002-01-17
WO2002072532A1	2002-09-19

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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