Title:
4-@(3754/24)AMINOMETHYL)CYCLOHEXANECARBOXAMIDE DERIVATIVE
Document Type and Number:
Japanese Patent JP3153015
Kind Code:
B2
Abstract:
PURPOSE: To provide a new 4-(aminomethyl)cyclohexanecarboxamide derivative digestive tract motion enhancer.
CONSTITUTION: The compound of formula I {R1 is H or of formula II (m is 0 or 1; X is CH2 or CH=CH; R5 is (substituted) phenyl, (substituted) naphthyl, (substituted) heterocyclic group, alkoxy-substituted alkyl or cycloalkyl); R2 is H or combined with R1 into homophthaloyl; R3 is (CH2)m-R6 [n is 1-3; R6 is H, alkyl, (substituted) phenyl, (alkyl-substituted) amino, CN, (alkyl-substituted) thiol, alkoxy, carbamoyl or of formula III (p is 0 or 1; q is 0-2; R7 is (substituted) heterocyclic group)]; R4 is H or combined with both R3 and bound N into 5 to 6membered ring} and an acid-added salt thereof, e.g. 4(benzamidomethyl)-N-(3-pyridyl)methyl-trans-cyclohexane-1-carboxamide. The compound of the formula I is effective for improving the general malaise of the upper digestive tracts, digestive tract function recovery after celiotomy, or aperitiveness.
Inventors:
Mitsuyuki Shimada
Mitsuto Okitsu
Ono Chichi
Mitsuto Okitsu
Ono Chichi
Application Number:
JP23838592A
Publication Date:
April 03, 2001
Filing Date:
September 07, 1992
Export Citation:
Assignee:
Suntory Limited
International Classes:
A61K31/16; A61K31/17; A61K31/275; A61P1/00; C07C237/22; C07C237/24; C07C255/24; C07C259/08; C07C271/28; C07C323/59; C07D213/40; C07D213/81; C07D401/04; (IPC1-7): C07C237/24; A61K31/16; A61P1/00; C07C237/22; C07C255/24; C07C259/08; C07C271/28; C07C323/59; C07D213/40
Domestic Patent References:
| JP625285A | ||||
| JP6122075A |
Other References:
【文献】J.Med.Chem.,Vol.15,No.3(1972)p.247-p.255
【文献】Acta.Pharm.Suecica,Vol.7,No.4(1970)p.441-p.448
【文献】Acta.Pharm.Suecica,Vol.7,No.4(1970)p.441-p.448
Attorney, Agent or Firm:
Aoki Akira (3 outside)