4-HYDROXY DERIVATIVES OF C-6 OR C-7 SUBSTITUTED STEROID AND MANUFACTURE

Japanese Patent JPS62298600

A

New steroids possessing aromatase-inhibiting activity are of formula (I> wherein the symbol ---- represents a single or a double bond; R is hydrogen, C1-C6 alkyl, a hydroxy-protecting group, or -CO-R4 where R4 is (a) hydrogen; (b) C1-C22 alkyl unsubstituted or substituted by carboxy, C4-C7 cycloalkyl, heterocyclyl or phenyl; or (c) phenyl, unsubstituted or substituted by C1-C4 alkyl, trifluoromethyl, halogen or C1-C4 alkoxy; or R is -SO2-R5 where R5 is C1-C6 alkyl or phenyl, the phenyl ring being unsubstituted or substituted by C1-C4 alkyl; one of R1 and R2 is hydrogen and the other is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or phenyl, the phenyl ring being unsubstituted or substituted by halogen, hydroxy, (in which each of R6 and R7 is hydrogen or C1-C6 alkyl), or where n is 1 to 6 and each of R8 and R9 is hydrogen or C1-C6 alkyl, or NR8R9 is a heterocyclic ring; and pharmaceutically acceptable salts thereof.

JPH02502997	[Title of the Invention] Cyclic hydrocarbon which has an amino alkyl side chain
WO/1999/063973	PHARMACEUTICAL COMPOSITIONS AND USES FOR ANDROST-5-ENE-3$g(b),17$g(b)-DIOL
JP2010180236	ORAL CONTRACEPTIVE TO PREVENT PREGNANCY AND DIMINISH PREMENSTRUAL SYMPTOMATOLOGY

FURANKO FUAUSUTEIINI
ROBERUTO DARETSUCHIYO
BUITSUTORIA BUIRA
FURANKO BUZETSUTEI
ENRIKO DEI SARURE

JP13841986A

December 25, 1987

June 16, 1986

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ERBA FARMITALIA

A61K31/565; A61P13/02; A61P15/00; C07J1/00; C07J17/00; C07J41/00; (IPC1-7): A61K31/565; C07J1/00; C07J41/00

Chika Takagi

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