Title:
4-(4-PYRIDAZINYL)PYRAZOLE DERIVATIVE
Document Type and Number:
Japanese Patent JP2005022972
Kind Code:
A
Abstract:
To provide a compound having a p38MAP kinase inhibiting action, therefore having the action of inhibiting the production of TNF-α, IL-1, IL-6, COX-II, etc., and being useful as a therapeutic agent against TNF-α-associated diseases, IL-1-associated diseases, IL-6-associated diseases, COX-II-associated diseases, etc.
The above compound is a pyridazinylpyrazole derivative represented by formula (1) (wherein Q is an optionally substituted aryl group or the like; R1 is a hydrogen atom, a lower alkoxyl group, or the like; R2 is a hydrogen atom or an optionally hydroxy-substituted lower alkyl group; and R3 is a hydrogen atom, a lower alkyl group, or the like) or a salt thereof.
Inventors:
MINAMI NOBUYOSHI
HASUMI KOICHI
OTA SHUJI
SATO HIDEICHIRO
SAITOU NORIHISA
DOI SATORU
KOBAYASHI MOTOHIRO
SATO JUN
ASANO SO
MATSUMOTO YASUHIRO
HASUMI KOICHI
OTA SHUJI
SATO HIDEICHIRO
SAITOU NORIHISA
DOI SATORU
KOBAYASHI MOTOHIRO
SATO JUN
ASANO SO
MATSUMOTO YASUHIRO
Application Number:
JP2001146270A
Publication Date:
January 27, 2005
Filing Date:
May 16, 2001
Export Citation:
Assignee:
TEIKOKU HORMONE MFG CO LTD
International Classes:
C07D401/14; A61K31/501; A61P1/00; A61P1/04; A61P1/18; A61P3/10; A61P7/00; A61P7/02; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P25/00; A61P25/28; A61P29/00; A61P29/02; A61P31/18; A61P33/06; A61P35/00; A61P37/02; A61P43/00; C07D403/04; C07D405/14; (IPC1-7): C07D401/14; A61K31/501; A61P1/00; A61P1/04; A61P1/18; A61P3/10; A61P7/00; A61P7/02; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P25/00; A61P25/28; A61P29/00; A61P29/02; A61P31/18; A61P33/06; A61P35/00; A61P37/02; A61P43/00; C07D403/04; C07D405/14
Attorney, Agent or Firm:
Heikichi Odashima
Youji Esumi
Youji Esumi