4-SUBSTITUTED-2-OXOAZETIDINE DERIVATIVE AND ITS PREPARATION

Title:

4-SUBSTITUTED-2-OXOAZETIDINE DERIVATIVE AND ITS PREPARATION

Document Type and Number:

Japanese Patent JPS57108066

Kind Code:

A

Abstract:

NEW MATERIAL:The 4-substituted-2-oxoazetidine derivative of formulaI[R1 is (OH-substituted) alkyl, phthalimido, benzyloxycarbonylamino or halogen; R2 is H, alkyl, alkylthio or arylthio; R3 and R4 are acyl or cyano].

EXAMPLE: [3S,4S]-4-Bisacetylmethyl-3-(1-hydroxyisopropyl)-2-oxoazetidine.

USE: An intermediate of carba-2-penem compound (an antibacterial agent or a β- lactamase inhibiting agent). It can be prepared economically.

PROCESS: The compound of formulaIis prepared by reacting the compound of formula II (R5 is carboxyl-protecting group) synthesized from penicillin with the compound of formula III in the presence of an alcohol and a base.

Inventors:

NUMATA MITSUO
YAMAOKA MASAYOSHI
NISHIMURA TATSUO
MATSUMOTO NORICHIKA

Application Number:

JP18214881A

Publication Date:

July 05, 1982

Filing Date:

November 12, 1981

Export Citation:

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Assignee:

TAKEDA CHEMICAL INDUSTRIES LTD

International Classes:

C07C205/42; C07D205/08; C07D205/085; C07D403/04; C07D477/00; C07D499/00; (IPC1-7): C07D205/08; C07D403/04; C07D487/04

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