4-SUBSTITUTED PIPERAZINE COMPOUND

Japanese Patent JP2768864

B2

PURPOSE: To obtain a new amine compd. as an intermediate of an amine steroid useful in the treatment of medulla spinalis injury, head injury, subarachnoid hemorrhage, asthma, muscular dystrophy, skin graft rejection, septic shock, etc.
CONSTITUTION: This amine compd. is a compd. selected from among 4-[(3- hydroxy-2-pyridyl)methyl]piperazine, 4-[6-(1-pyrrolidinyl)-2-pyridyl]piperazine, 4-[3-amino-6-diethylamino]-2-pyridyl]piperazine, 4-[6-(diethylamino)-3-(dimethylamino-2-pyridyl)piperazine, etc., its salt or hydrate. For example, 4-[(3-hydroxy-2-pyridyl)methyl]piperazine is obtd. by allowing t-butyloxycarbonylpiperazine to react with 3-hydroxypyridine and allowing the resultant t-butyloxy ester of 4-[(3-hydroxy-2-pyridyl)methyl]-1- piperazinecarboxylic acid to react with trifluoroacetic acid.

WO/2024/058427	ANTIVIRAL COMPOSITION CONTAINING GINSENG EXTRACT AND STEROID COMPOUND AS ACTIVE INGREDIENTS
JP2962484	[Title of the Invention] New N, N, N', N'-substitution-6- (1-piperazinyl) -2,5-pyridinediamine derivatives, methods for producing them, intermediates of this method, and their agents. Use and pharmaceutical compositions containing them
WO/2011/046978	STEROIDAL COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF

John M McCall
Donald E. Ear
E. John Jacobsen
Frederick Jay Van Dournik
John Earl Palmer
Harold A. Kerness

JP842892A

June 25, 1998

January 21, 1992

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The Up John Company

A61K31/58; A61P1/04; A61P3/06; A61P9/00; A61P9/10; A61K31/57; A61P11/00; A61P17/00; A61P35/00; A61P37/08; A61P43/00; C07D213/65; C07D213/74; C07D239/48; C07D239/50; C07D249/14; C07D251/54; C07D251/70; C07D295/135; C07D307/68; C07D333/66; C07D401/14; C07J3/00; C07J5/00; C07J7/00; C07J21/00; C07J31/00; C07J41/00; C07J43/00; (IPC1-7): C07D213/65; C07D213/74; C07D239/48; C07D251/54

Aoyama Ryo (1 person outside)

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