Title:
呼吸器多核体ウイルスのＲＮＡ複製の阻害剤としての４’‐ビニル置換ヌクレオシド誘導体
Document Type and Number:
Japanese Patent JP2017529375
Kind Code:
A
Abstract:
本出願は、可変置換基が本明細書で定める通りである式（Ｉ）の化合物を開示する。式（Ｉ）の化合物及び式Ｉの化合物を含む医薬組成物は、ＲＳＶによって媒介される疾患の治療に有用である。
Inventors:
Smith,mark
Crump, Claus G
Crump, Claus G
Application Number:
JP2017516420A
Publication Date:
October 05, 2017
Filing Date:
September 25, 2015
Export Citation:
Assignee:
Revo Science LLC
International Classes:
C07H19/10; A61K31/7125; A61P31/12; A61P43/00; C07H19/11; C07H19/20
Domestic Patent References:
| JP2006528972A | 2006-12-28 | |||
| JP2004035546A | 2004-02-05 | |||
| JP2004522694A | 2004-07-29 |
Foreign References:
| WO2005020885A2 | 2005-03-10 | |||
| US20030236216A1 | 2003-12-25 | |||
| WO2013142525A1 | 2013-09-26 | |||
| WO2013096679A1 | 2013-06-27 |
Other References:
KODAMA EI-ICHI ET AL.: "4'-ethynyl nucleoside analogs: potent inhibitors of multidrug-resistant human immunodeficiency virus", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 45, no. 5, JPN6019037885, 2001, pages 1539 - 1546, XP001127402, ISSN: 0004124830, DOI: 10.1128/AAC.45.5.1539-1546.2001
SMITH DAVID B. ET AL.: "Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepat", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, JPN6019037886, 2007, pages 2570 - 2576, ISSN: 0004124831
VILAR SANTIAGO ET AL.: "Probabilistic Neural Network Model for the In Silico Evaluation of Anti-HIV Activity and Mechanism o", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, JPN6019037889, 2006, pages 1118 - 1124, ISSN: 0004124832
NOMURA MAKOTO ET AL.: "Nucleosides and Nucleotides. 185. Synthesis and Biological Activities of 4'α-C-Branched-Chain Suga", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, JPN6019037891, 1999, pages 2901 - 2908, XP000915083, ISSN: 0004124833, DOI: 10.1021/jm990050i
REGISTRY(STN)[ONLINE], JPN7019003181, 2008, ISSN: 0004124834
SMITH DAVID B. ET AL.: "Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepat", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, JPN6019037886, 2007, pages 2570 - 2576, ISSN: 0004124831
VILAR SANTIAGO ET AL.: "Probabilistic Neural Network Model for the In Silico Evaluation of Anti-HIV Activity and Mechanism o", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, JPN6019037889, 2006, pages 1118 - 1124, ISSN: 0004124832
NOMURA MAKOTO ET AL.: "Nucleosides and Nucleotides. 185. Synthesis and Biological Activities of 4'α-C-Branched-Chain Suga", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, JPN6019037891, 1999, pages 2901 - 2908, XP000915083, ISSN: 0004124833, DOI: 10.1021/jm990050i
REGISTRY(STN)[ONLINE], JPN7019003181, 2008, ISSN: 0004124834
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Naoshi Nakata
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Naoshi Nakata