Title:
(4R,5S,6S)-3-(((2R,3R)-2-((((S)-2-アミノ-3-メチル-1-オキソブチル)メチル)テトラヒドロ-3-フラニル)チオ)-6-((R)-1-ヒドロキシエチル)-4-メチル-7-オキソ-1-アザビシクロ(3.2.0)ヘプタ-2-エン-2-カルボン酸の改良された製造
Document Type and Number:
Japanese Patent JP2004504322
Kind Code:
A
Abstract:
The invention is a process improvement for producing the carbapenem antibacterial agent (4R, 5S, 6S)-3-[[2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid by hydrogenation of 4-nitrobenzyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-{[2R,3R)-2-({[(2S)-3-methyl-2-({[4-nitrobenzyl)oxy]carbonyl}amino)butanoyl]amino}methyl)-tetrahydrofuran-3-yl]thio}-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate in a biphasic solvent mixture comprising a water portion and an organic solvent portion, not containing an acid acceptor. The water portion is separated from the organic solvent portion and (4R,5S,6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[R-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid is isolated from the separated water portion by lyophilization or reverse osmosis.
Inventors:
Tarek Mansour
Fake-En Sum
Yang-Lee Lin
John Li
Fake-En Sum
Yang-Lee Lin
John Li
Application Number:
JP2002512185A
Publication Date:
February 12, 2004
Filing Date:
July 10, 2001
Export Citation:
Assignee:
Wyeth
International Classes:
C07D477/00; A61K31/407; A61P31/04; C07B61/00; C07D477/08; C07D477/20; (IPC1-7): C07D477/00
Attorney, Agent or Firm:
Aoyama Aoi
Osamu Kawamiya
Mitsuo Tanaka
Osamu Kawamiya
Mitsuo Tanaka