Title:
（４Ｓ，４ＡＳ，５ＡＲ，１２ＡＳ）−４−ジメチルアミノ−３，１０，１２，１２Ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４Ａ，５，５Ａ，６，１１，１２Ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法
Document Type and Number:
Japanese Patent JP2014520077
Kind Code:
A
Abstract:
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino- 3,10, 12, 12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]- 1, 11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethyl-amino-3,10,12,12a-tetrahydroxy-7- [(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene- 2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed.
Inventors:
Coal tar, Catherine
Johnston, Sean, M.
セイェディ, ファルザネー
Johnston, Sean, M.
セイェディ, ファルザネー
Application Number:
JP2014510546A
Publication Date:
August 21, 2014
Filing Date:
May 14, 2012
Export Citation:
Assignee:
パラテック Fame shoe tee カルズ In condominium lei テッド
Warner チルコット company LLC
Warner チルコット company LLC
International Classes:
C07C239/20; A61K31/65; A61P17/00; A61P31/04; C07B57/00
Domestic Patent References:
| JP2010513527A | 2010-04-30 | |||
| JP2011513404A | 2011-04-28 |
Foreign References:
| US20080312193A1 | 2008-12-18 | |||
| WO2009143509A1 | 2009-11-26 |
Other References:
芦澤一英 編, 医薬品の多形現象と晶析の科学, JPN7015003062, 20 September 2002 (2002-09-20), JP, pages 305 - 317, ISSN: 0003188810
Attorney, Agent or Firm:
Yusuke Hiraki
Setsu Fujita
Arai Eiichi
Natsuo Tanaka
Naoko Kikuta
Fujii Love
Setsu Fujita
Arai Eiichi
Natsuo Tanaka
Naoko Kikuta
Fujii Love