Title:
5-(2-CARBOXY-2-HALOGENOVINYL)URACIL NUCLEOSIDE
Document Type and Number:
Japanese Patent JPS59163395
Kind Code:
A
Abstract:
NEW MATERIAL:A compound shown by the formula I (R1 is H, or OH; X is halogen).
EXAMPLE: 1-β-D-Aravinofuranosyl-5-(2-bromo-2-carboxyvinyl) uracil.
USE: An intermediate for synthesizing an antiviral compound.
PREPARATION: A 5-formyluracil nucleoside shown by the formula II is reacted with a phosphorane shown by the formula III (R2 and R3 are alkyl or aryl) to give a 5-(2-alkoxy or aloxycarbonyl-2-halogenovinyl)uracil nucleotide shown by the formula IV. This compound is then hydrolyzed in a water using an alkali or a water-containing solvent at 0°CW room temperature for several hours.
Inventors:
IKEDA KAZUYOSHI
Application Number:
JP3795583A
Publication Date:
September 14, 1984
Filing Date:
March 08, 1983
Export Citation:
Assignee:
YAMASA SHOYU KK
International Classes:
C07H19/073; C07H19/06; C07H19/09; (IPC1-7): C07H19/06