癌の治療用の5-アミノ-2,4,7-トリオキソ-3,4,7,8-テトラヒドロ-2H-ピリド’2,3-d!ピリミジン誘導体及び関連化合物

Title:

癌の治療用の5-アミノ-2,4,7-トリオキソ-3,4,7,8-テトラヒドロ-2H-ピリド’2,3-d!ピリミジン誘導体及び関連化合物

Document Type and Number:

Japanese Patent JP4163738

Kind Code:

B2

Abstract:

The present invention relates to a pyrimidine compound represented by the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a pharmaceutical agent for the prophylaxis or treatment of a disease caused by undesirable cell proliferation, particularly an antitumor agent, which contains such compound. The compound of the present invention has superior undesirable cell proliferation suppressing action, particularly, an antitumor action, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, antirheumatoid agent and the like. In addition, by the combined use with other antitumor agent such as alkylating agent, metabolism antagonist and the like, it can be a more effective antitumor agent.

Inventors:

Kawasaki Hisa
Hiroyuki Abe
Kazuhide Hayakawa
Tetsuya Iida
Shinichi Kikuchi
Naoyuki Yamaguchi
Nanayama Toyodo
Hironori Kurachi
Masahiro Tamaru
Yoshikazu Hori
Mitsuru Takahashi
Takayuki Yoshida
Toshiyuki Sakai

Application Number:

JP2006551659A

Publication Date:

October 08, 2008

Filing Date:

June 10, 2005

Export Citation:

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