Title:
AMPK活性化作用を有する5-オキシベンズイミダゾールおよび5-オキシアザベンズイミダゾール誘導体
Document Type and Number:
Japanese Patent JP6372891
Kind Code:
B2
Abstract:
Provided is a compound useful as an AMPK activator. A compound represented by the formula (In the formula, Y is a substituted or unsubstituted alkyl (excluding cases of an unsubstituted methyl or unsubstituted ethyl), substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, etc., Z is -CR5= or -N=, R1 is hydrogen or a substituted or unsubstituted alkyl, R2 is hydrogen or a substituted or unsubstituted alkyl (excluding cases of an unsubstituted methyl or trifluoromethyl), substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, etc., R3, R4 and R5 are each independently hydrogen, halogen, hydroxyl, cyano, nitro, carboxy, a substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, etc.) or a pharmaceutically acceptable salt thereof.
Inventors:
Eiichi Kojima
Yu Hyuga
Yusuke Tamura
Fujioka Masahiko
Fixed mutsumi
Yu Hyuga
Yusuke Tamura
Fujioka Masahiko
Fixed mutsumi
Application Number:
JP2015513798A
Publication Date:
August 15, 2018
Filing Date:
April 23, 2014
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07D471/04; A61K31/4184; A61K31/437; A61K31/444; A61K31/4545; A61K31/4709; A61K31/496; A61K31/497; A61K31/506; A61K31/5377; A61K31/538; A61P3/04; A61P3/06; A61P3/10; A61P9/12; A61P43/00; C07D493/04; C07D519/00
Domestic Patent References:
| JP2011511008A |
Foreign References:
| WO2012033149A1 | ||||
| WO2013011932A1 | ||||
| WO2012064569A1 |
Other References:
Toyo Kaiya et al,Reactions of 1-methylbenzimidazole derivatives with m-chloroperoxybenzoic acid,Bioorganic & Medicinal Chemistry Letters,米国,Elsevier,1998年,Vol.8, No.6,p.625-630
Attorney, Agent or Firm:
Kenichi Sugita
Hideaki Watanabe
Hideaki Watanabe
Previous Patent: 乳酸菌増殖促進剤、制御性T細胞増加剤、乳酸菌増殖促進方法、制御性T細...
Next Patent: CLEANING SOLUTION FOR SURFACE OF SUPERINVAR SUBJECTED TO ELECTRIC SPARK MACHINING
Next Patent: CLEANING SOLUTION FOR SURFACE OF SUPERINVAR SUBJECTED TO ELECTRIC SPARK MACHINING