Title:
変形性関節症の治療のためのＡＤＡＭＴＳ阻害剤としての５−［（ピペラジン−１−イル）−３−オキソ−プロピル］−イミダゾリジン−２，４−ジオン誘導体
Document Type and Number:
Japanese Patent JP6636539
Kind Code:
B2
Abstract:
The present invention discloses compounds according to formula I:Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and the compounds of formula I for use in methods of treatment and for use in methods of prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.
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Inventors:
Frank Laurent Brebion
Luke Jonathan Albay
David Amantini
Pierre Marc Marie Joseph Depres
Romain Luc Marie Goth Mini
Helene Marie Jari
Christophe Paikuoto
Marie Laurence Claire Balin
Frederik Andre De Seunink
Iuliana Ekaterina Pop-Botez
Luke Jonathan Albay
David Amantini
Pierre Marc Marie Joseph Depres
Romain Luc Marie Goth Mini
Helene Marie Jari
Christophe Paikuoto
Marie Laurence Claire Balin
Frederik Andre De Seunink
Iuliana Ekaterina Pop-Botez
Application Number:
JP2017551003A
Publication Date:
January 29, 2020
Filing Date:
December 18, 2015
Export Citation:
Assignee:
Galapagos N.V.
International Classes:
C07D233/78; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61K45/00; A61P19/02; A61P29/00; A61P43/00; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D403/12; C07D403/14; C07D405/04; C07D405/12; C07D405/14; C07D413/14; C07D417/12; C07D417/14; C07D471/04
Domestic Patent References:
| JP2009523795A | ||||
| JP2004527515A |
Foreign References:
| WO2014066151A1 |
Attorney, Agent or Firm:
Toru Ishikawa