Title:
【発明の名称】5′-デオキシ-シチジン誘導体
Document Type and Number:
Japanese Patent JP3081185
Kind Code:
B2
Abstract:
Novel 5'-deoxy-cytidine derivatives represented by the general formula (I) wherein R1 is a hydrogen atom or a group easily hydrolyzable under physiological conditions; R2 is a hydrogen atom, or -CO-OR4 group [wherein R4 is a saturated or unsaturated, straight or branched hydrocarbon group consisting of one to fifteen carbon atoms, or a group of the formula -(CH2)n-Y (in which Y is cyclohexyl or phenyl; n is an integer from 0 to 4)]; R3 is a hydrogen atom, bromo, iodo, cyano, a C1-4 alkyl group [which may be substituted with halogen atom(s)], a vinyl or ethynyl group [which may be substituted with halogen atom(s), C1-4 alkyl, cycloalkyl, aralkyl, or aromatic ring which may have one or more hetero atom(s)], or an aralkyl group which may be substituted for use in medical therapy, especially tumor therapy.
Inventors:
Kazuo Hattori
Toru Ishikawa
Hideo Ishizuka
Yasunori Kawachi
Nobuhiro Oikawa
Nobuo Shinma
Hitomi Suda
Toru Ishikawa
Hideo Ishizuka
Yasunori Kawachi
Nobuhiro Oikawa
Nobuo Shinma
Hitomi Suda
Application Number:
JP15257498A
Publication Date:
August 28, 2000
Filing Date:
June 02, 1998
Export Citation:
Assignee:
F. Hoffman-La Rochille Age
International Classes:
A01N43/04; A61K31/505; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7068; A61K31/7072; A61P35/00; A61P43/00; C07D239/553; C07H19/067; C07H19/06; (IPC1-7): C07H19/06; A61K31/7068; A61K31/7072; A61P35/00; A61P43/00
Other References:
Ｃｏｌｌｅｃｔ．Ｃｚｅｃｈ．Ｃｈｅｍ．Ｃｏｍｍｕｎ．，Ｖｏｌ．６１（１９９６）ｐ．６２７−６４４
Attorney, Agent or Firm:
Hajime Tsukuni (3 outside)