PURPOSE: A 5-lipoxygenase inhibitor useful as a remedy for bronchial asthma, allergic diseases, etc., showing improved inhibitory action on 5-lipoxygenase, comprising a specific compound of vitamin E derivative or its salt as an active ingredient.
CONSTITUTION: A compound shown by formula I [R1 is H or nicotinoyl; R2 is OH, nicotinoyloxy, guanidinocarbonyl or group shown by formula II (n is 1W3 integer)] or its salt as a 5-lipoxygenase inhibitor. Bis[2-(6-hydroxy-2,5,7,8- tetramethyl-3,4-dihydro-2H-benzopy-ran-2-ly)ethyl]thiodiacetate, etc., may be preferably cited as the compound shown by formula I. The inhibitor suppresses 5-hydroxyeicosatetraenoic acid production from arachidonic acid and has improved inhibitory action on 5-lipoxygenase and useful for remedying allergic diseases, immunological diseases, inflammatory diseases, etc.
TERASAWA MICHIO
OCHI HIROSHI
KANEHIRA KOICHI
SHIONO MANZO
FUJITA YOSHIJI
NISHIDA TAKUJI
YAMAHARA JOJI
KURARAY CO