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Title:
MEK阻害物質としての5-置換-2-フェニルアミノ-ベンズアミド類
Document Type and Number:
Japanese Patent JP4090070
Kind Code:
B2
Abstract:
An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R 1 , R 2 , R 3 , R 4 , and X are the same as defined in the present patent application].

Inventors:
Yoshiaki Isshiki
Yasunori Kawauchi
Mizusaku Eisaku
Hitoshi Iikura
Yasuaki Matsubara
Shinji Tsujii
Nobuo Shinma
Miwa Masataka
Satoshi Aida
Masami Kawauchi
Murata Tsuyoshi
Aso Kosuke
Application Number:
JP2006529328A
Publication Date:
May 28, 2008
Filing Date:
July 26, 2005
Export Citation:
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Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07C259/10; A61K31/166; A61K31/4015; A61K31/42; A61K31/421; A61K31/45; A61K31/513; A61K31/535; A61K31/5375; A61P3/10; A61P7/00; A61P9/04; A61P9/08; A61P9/10; A61P17/06; A61P19/02; A61P25/28; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P43/00; C07C229/58; C07C229/64; C07C317/04; C07C323/12; C07D207/27; C07D211/76; C07D239/10; C07D261/04; C07D263/22; C07D265/02; C07D265/32; C07D273/01
Domestic Patent References:
JP2003527379A
Foreign References:
WO2005028426A2
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Kazuya Kawamoto