55SUBSTITUTEDD22CARBOXYLIC ACID COMPOUND AND PREPARATION THEREOF

Title:

55SUBSTITUTEDD22CARBOXYLIC ACID COMPOUND AND PREPARATION THEREOF

Document Type and Number:

Japanese Patent JPS52118454

Kind Code:

A

Abstract:

5-Substituted indan-2-carboxylic acids and functional derivatives thereof having inflammation-reducing properties have the general formula in which R is a phenyl, phenyl-lower alkenyl, phenyl-lower alkyl, phenyl substituted by at least one of the halogens, lower alkyl, lower alkoxy, acetamido, amino, lower dialkylamino, nitro, phenyl, lower alkylsulfonyl, lower dialkylaminosulfonyl and sulfamido, cyclohexyl, furyl, lower alkylfuryl, thienyl, halothienyl, lower alkylthienyl, or pyridyl group and R' is a hydroxyl, lower alkoxy, lower dialkylaminoalkoxy, cinnamoylamido lower alkoxy, 2-hydroxyethylamino, amino or lower dialkylaminoalkyl amino group. Besides the esters and amides, the functional derivatives of the acids include the pharmacologically acceptable salts of the above compounds. The compounds are also of low toxicity, have analgesic activity and exert an antipyretic effect.

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Inventors:

MISHIERU BEIZA
FURANSHISU SOOTERU
JIYAN KUROODO DOPAN
ANII BETOBEDE MACHIBE

Application Number:

JP228177A

Publication Date:

October 04, 1977

Filing Date:

January 12, 1977

Export Citation:

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Assignee:

LIPHA

International Classes:

A61K31/16; A61K31/165; A61K31/19; A61K31/195; A61K31/215; A61K31/34; A61K31/341; A61K31/44; C07C59/84; A61K31/4406; A61P25/04; A61P29/00; C07C45/00; C07C45/46; C07C45/63; C07C49/784; C07C49/84; C07C51/00; C07C51/09; C07C62/38; C07C67/00; C07C69/757; C07C201/00; C07C205/57; C07C213/00; C07C219/12; C07C227/00; C07C227/10; C07C227/16; C07C227/18; C07C229/46; C07C231/00; C07C231/12; C07C233/22; C07C233/38; C07C233/54; C07C233/60; C07C235/82; C07D213/50; C07D213/80; C07D307/46; C07D333/22; C07D333/24; C07D333/28; A61K31/185; (IPC1-7): A61K31/16; A61K31/34; A61K31/44; C07C61/36; C07C69/74; C07C103/183; C07D213/80; C07D307/46; C07D333/22

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