Title:
(5S,10S)−10−ベンジル−16−メチル−11,14,18−トリオキソ−15,17,19−トリオキサ−2,7,8−トリチア−12−アザヘンイコサン−5−アミニウム(E)−3−カルボキシアクリレート塩の調製のための工業的プロセス
Document Type and Number:
Japanese Patent JP2018531946
Kind Code:
A
Abstract:
本発明は、Xがフマレートである式(I)の(5S,10S)-10-ベンジル-16-メチル-11,14,18-トリオキソ-15,17,19-トリオキサ-2,7,8-トリチア-12-アザヘンイコサン-5-アミニウム(E)-3-カルボキシアクリレート塩の調製のための工業的プロセスに関する。このプロセスは、式(I)の所望の生成物を得るために、速度論的分割、ジスルフィド化合物の形成、ペプチドカップリング、およびアニオン交換反応といった重要な連続工程を含む。
Inventors:
Porus Helve
Le Fevre Roi
Jiao Shin Jun
Gamberny Luca
De Rosa The Sabrina
Veraldi Rosario
Le Fevre Roi
Jiao Shin Jun
Gamberny Luca
De Rosa The Sabrina
Veraldi Rosario
Application Number:
JP2018519343A
Publication Date:
November 01, 2018
Filing Date:
October 14, 2016
Export Citation:
Assignee:
PHARMALEADS
International Classes:
C07C319/22; C07B57/00; C07C227/18; C07C229/08; C07C319/02; C07C319/28; C07C323/56; C07C327/32
Domestic Patent References:
JP2009513600A | 2009-04-02 | |||
JP2011522797A | 2011-08-04 | |||
JPH11228532A | 1999-08-24 | |||
JP2005508308A | 2005-03-31 |
Foreign References:
US5552397A | 1996-09-03 |
Other References:
BABAK KABOUDIN: "RESOLUTION OF ENANTIOMERS OF NOVEL C2-SYMMETRIC AMINOBISPHOSPHINIC ACIDS VIA 以下備考", CHIRALITY, vol. VOL:27, NR:1, JPN5018006792, 16 January 2015 (2015-01-16), US, pages 71 - 74, ISSN: 0004340697
CAMPBELL I G M: "THE CHRYSANTHEMUMCARBOXYLIC ACIDS. IV. OPTICAL RESOLUTION OF THE CHRYSANTHEMIC ACIDS", JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, vol. 3, JPN5018006793, April 1952 (1952-04-01), GB, pages 189 - 192, XP009068559, ISSN: 0004340698
PORAS, HERVE ET AL.: "New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment", JOURNAL OF MEDICINAL CHEMISTRY, vol. Vol.57(13), JPN6020033652, 2014, pages 5748 - 5763, ISSN: 0004340699
CAMPBELL I G M: "THE CHRYSANTHEMUMCARBOXYLIC ACIDS. IV. OPTICAL RESOLUTION OF THE CHRYSANTHEMIC ACIDS", JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, vol. 3, JPN5018006793, April 1952 (1952-04-01), GB, pages 189 - 192, XP009068559, ISSN: 0004340698
PORAS, HERVE ET AL.: "New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment", JOURNAL OF MEDICINAL CHEMISTRY, vol. Vol.57(13), JPN6020033652, 2014, pages 5748 - 5763, ISSN: 0004340699
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto