Title:
6-アルキリデンアンドロスト-1,4-ジエン-3-オンを取得するための方法
Document Type and Number:
Japanese Patent JP2011506405
Kind Code:
A
Abstract:
6-alkylidenandrost-1,4-dien-3-ones of general formula (I), wherein R is H o alkyl; R 1 y R 2 , independently of one another, represent H, OR 3 , OC(=O) R 4 or O-(GPH), wherein R 3 is H; C 1 -C 6 alkyl or aryl; R 4 is H or C 1 -C 6 alkyl,; and GPH is a hydroxyl protecting group; or R 1 and R 2 , together with the carbon atom to which they are bonded, form a carbonyl group or equivalent or a cyclic ketal; can be obtained by a process comprising subjecting the corresponding 6-alkyliden-4-androsten-3-one to a dehydrogenation reaction in the 1,2 position in the presence of a quinine, a silylating agent and a strong acid.
Inventors:
Bermejo Gonzalez, Francisco
Marcos Escribano, Jose Andres
Gutierrez Fuentes, Louis Herald
Iglesias Retuelto, Jesus Miguel
Lorente Bonde-Larsen, Antonio
Marcos Escribano, Jose Andres
Gutierrez Fuentes, Louis Herald
Iglesias Retuelto, Jesus Miguel
Lorente Bonde-Larsen, Antonio
Application Number:
JP2010537463A
Publication Date:
March 03, 2011
Filing Date:
December 12, 2008
Export Citation:
Assignee:
CRYSTAL PHARMA, S.A.
International Classes:
C07J1/00
Attorney, Agent or Firm:
Konno Akio