Title:
6-カルボキサミドジヒドロピラン誘導体
Document Type and Number:
Japanese Patent JP4162712
Kind Code:
B2
Abstract:
PCT No. PCT/AU96/00289 Sec. 371 Date Jan. 12, 1998 Sec. 102(e) Date Jan. 12, 1998 PCT Filed May 13, 1996 PCT Pub. No. WO96/36628 PCT Pub. Date Nov. 21, 1996Compounds of formula (I), wherein R1 represents OR5, SR5, NR5R6, N(OR5)R6 or N(NR5R6)R6; X represents OH, N3, NR3R4 or NR4CO2R15; Y represents H or NHR2; R2 represents a group SO2R7 or COR7; R3 represents H, C1-6alkyl or C(=NR8)NR9R10; R4 represents H or C1-6alkyl; R5 represents H, C1-20alkyl, C3-8cycloalkyl, C2-20alkenyl, C2-20alkynyl, CHR11COR12 or C1-20alkyl substituted by one or more groups selected from NR13R14, NR13COR14, CO2R13, OR13, C3-8cycloalkyl and optionally substituted aryl; each R6 independently represents H, C1-6alkyl, C3-8cycloalkyl, C2-6alkenyl, C2-20alkynyl, aryl or C1-4alkyl substituted by one or more groups selected from NR13R14, COR13, C3-8cycloalkyl, CN, N3, OR13 and optionally substituted aryl; or R5 and R6 together form a C2-6 hydrocarbon chain which may optionally contain a group NR13 which chain is optionally substituted by 1, 2, 3 or 4 groups selected from oxo and C1-6alkyl groups which groups may optionally be substituted by hydroxy or optionally substituted aryl; R7 represents C1-6alkyl optionally substituted by one or more halogen atoms, C3-8cycloalkyl or optionally substituted aryl; R8, R9 and R10 each independently represent H, C1-6alkyl, amino, hydroxy, cyano or nitro; R11 represents the side chain of a D- or L-amino acid; R12 represents NR13R14, OR13 or R13; each R13 and each R14 independently represents H, C1-6alkyl or optionally substituted arylC1-4alkyl; R15 represents C1-6alkyl; and their pharmaceutically acceptable derivatives are neuraminidase inhibitors useful in the treatment of viral infections.
Inventors:
Cherry, peter
Howes, Peter
Smith, paul
Stephen the Soulis
Howes, Peter
Smith, paul
Stephen the Soulis
Application Number:
JP53439196A
Publication Date:
October 08, 2008
Filing Date:
May 13, 1996
Export Citation:
Assignee:
BIOTA SCIENTIFIC MANAGEMENT PTY LTD
International Classes:
C07D309/28; A61K31/35; A61K31/351; A61K31/38; A61K31/40; A61K31/4025; A61K31/44; A61K31/443; A61K31/4433; A61P31/12; A61P31/16; C07D309/30; C07D405/12; C07D409/12
Domestic Patent References:
| JP5507068A |
Other References:
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry, 1995年, (9), 1181-1187
Biochemistry, 1995年, 34(10), 3144-3151
Monatsh. Chem., 1970年, 101(3), 639-647
Carbohydrate Research, 1994年, 262(2), 297-310
Biochemistry, 1995年, 34(10), 3144-3151
Monatsh. Chem., 1970年, 101(3), 639-647
Carbohydrate Research, 1994年, 262(2), 297-310
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota