6-HETEROARYL-2-(4-TRIFLUOROMETHYLPHENYL) PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Title:

6-HETEROARYL-2-(4-TRIFLUOROMETHYLPHENYL) PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Document Type and Number:

Japanese Patent JP2001220389

Kind Code:

A

Abstract:

To provide a compound having excellent antirheumatic action and useful as an agent for the treatment and prevention of rheumatic diseases such as rheumatoid arthritis, Behcet's syndrome and ankylosing spondylitis, immuneological inflammatory diseases such as autoimmune inflammatory diseases, e.g. disseminated sclerosis, systemic lupus erythematosus and Sjoegren's syndrome.

The invention discloses the 6-heteroaryl-2-(4- trifluoromethylohenyl) pyrimidine derivative of formula (R1 is H, a lower alkyl or the like; R2 is a lower alkyl, a cycloalkyl or the like; R3 is H or a lower alkyl; R4 is a halogen atom; and R5 is a non-substituted or substituted heteroaryl group) and pharmaceutical composition containing the derivative.

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Inventors:

MURATA KOYA
KONDO MASAKI
ITOU MARI

Application Number:

JP2000030187A

Publication Date:

August 14, 2001

Filing Date:

February 08, 2000

Export Citation:

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Assignee:

DAINIPPON PHARMACEUTICAL CO

International Classes:

C07D401/04; A61K31/506; A61P29/00; A61P37/02; C07D405/04; C07D409/04; (IPC1-7): C07D401/04; A61K31/506; A61P29/00; A61P37/02; C07D405/04; C07D409/04

Attorney, Agent or Firm:

Takuyuki Yoshioka

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