To provide a new 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt useful as an anti-HIV agent.
The invention relates to a compound represented by the general formula [I], a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt; and a pharmaceutical composition, an anti-HIV agent, and an HIV integrase inhibitor, each comprising the compound. The compound has an action of inhibiting the HIV integrase activity, and therefore is useful as an anti-HIV agent or a therapeutic or prophylactic agent for AIDS. By using in combination with other anti-HIV agent such as a protease inhibitor and a reverse transcriptase inhibitor, the compound can act as a more effective anti-HIV agent. Further, because of its high inhibitory activity specifically against an integrase, the compound can act as an agent which is safe for a human body and has few adverse side-effects.
ARAMAKI HISAAKI
YAMASHITA MASAKI
INOUE AKIFUMI
KAWAKAMI HIROSHI
SHINKAI HISASHI
NAKAMURA HIROSHI
MATSUZAKI YUJI
WAMAKI SHUICHI
