Title:
6-O-SUBSTITUTED KETOLIDE HAVING ANTIBACTERIAL ACTIVITY
Document Type and Number:
Japanese Patent JP2013047243
Kind Code:
A
Abstract:
To provide new semi-synthesized macrolides having antibacterial activity, a pharmaceutical composition including these compounds, and a medical treatment method of remedy.
There is provided a 6-O-substituted erythromycin ketolide derivative expressed by formula (IV-A), where in formula, Rc is hydrogen or a hydroxy-protective group; R is a substituted methyl group; A, B, D and E are each selected from hydrogen, a 1-6C alkyl which may be substituted by a substituent, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, hydroxy, 1-6C alkoxy, and halogen of Br, Cl, F or I, or the like, under conditions that at least two of A, B, D and E are both hydrogen.
Inventors:
OR YAT SUN
MA ZHENKUN
CLARK RICHARD F
CHU DANIEL T
PLATTNER JACOB J
MA ZHENKUN
CLARK RICHARD F
CHU DANIEL T
PLATTNER JACOB J
Application Number:
JP2012228250A
Publication Date:
March 07, 2013
Filing Date:
October 15, 2012
Export Citation:
Assignee:
ABBOTT LAB
International Classes:
C07H17/08; A61K31/7048; A61K31/7056; A61P31/04
Foreign References:
| WO1993021200A1 | 1993-10-28 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office