NEW MATERIAL: A compd. expressed by formula I and II (X is CH2CH2 or CH=CH; R1 and R4 are alkyl, CF3 cyclopropyl, (substd.) phenyl, 2-pyridyl, 2-pyrimidinyl, CH2OH, etc., and R1 is moreover CH2OH or S(O)nR ((n) is 0-2; R is alkyl, phenyl, etc.; R2 is H, alkyl, CF3, cyclopropyl, (substd.) phenyl, etc.; R3 is H, alkyl, CN, CH2NH2, NO2, etc.), and its N-oxide.
EXAMPLE: Trans-tetrahydro-4-hydroxy-6-[2-(2-methyl-4-phenyl-3-pyridinyl)ethyl]-2 H-pyrane-2-one.
USE: A strong inhibitor of cholesterol biosynthesis.
PROCESS: The compd. expressed by formula I is obtained by allowing the compd. expressed by formula III to react with an alkali metal salt of a dianion of methylacetoacetate, then reducing an obtained compd. expressed by formula IV to obtain an ester compd. expressed by formula V, then hydrolyzing and cyclizing the ester.
MAAKU UOORESU KURESUUERU
BURUUSU DEIBITSUDO ROSU
DORAGO ROBAATO SURISUKOBITSUKU
