7-および9-カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール-アミノ置換テトラサイクリン化合物

Title:

7-および9-カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール-アミノ置換テトラサイクリン化合物

Document Type and Number:

Japanese Patent JP2004505012

Kind Code:

A

Abstract:

Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.

Inventors:

Nelson Mark El.
Levy Stuart Bee.
Frechet Roger
Borser Todd E.
Ismail Mohammed Wai.

Application Number:

JP2001572456A

Publication Date:

February 19, 2004

Filing Date:

March 30, 2001

Export Citation:

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Assignee:

TRUSTEES OF TUFTS COLLEGE

International Classes:

A61K31/17; A61K31/325; A61K31/65; A61P31/04; C07C235/84; C07C237/04; C07C237/26; C07D277/20; C07C237/48; C07C271/30; C07C271/58; C07C275/40; C07C275/42; C07C311/54; C07C311/60; C07C333/08; C07C335/20; C07D277/42; C07D277/56; C07J41/00; C07C; (IPC1-7): C07C237/04; A61K31/65; A61P31/04; C07C271/30; C07C275/40; C07C311/54; C07D277/42

Domestic Patent References:

JPS5154564A	1976-05-13
JPH11504916A	1999-05-11
JPH06206855A	1994-07-26
JPH06228072A	1994-08-16
JPH05255219A	1993-10-05
JPH11504916A	1999-05-11
JPH06206855A	1994-07-26
JPH06228072A	1994-08-16
JPH05255219A	1993-10-05
JPS5154564A	1976-05-13

Foreign References:

WO1999037306A1	1999-07-29
US3579579A	1971-05-18
WO1999037306A1	1999-07-29
US3579579A	1971-05-18

Other References:

JPN6011014443; ＢＡＲＤＥＮ，Ｔ．Ｃ．　ｅｔ　ａｌ．: '"Ｇｌｙｃｙｌｃｙｃｌｉｎｅｓ"．　３．　９-Ａｍｉｎｏｄｏｘｙｃｙｃｌｉｎｅｃａｒｂｏｘａｍｉｄｅｓ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．３７，　Ｎｏ．２０, 1994, ｐ．３２０５-３２１１
JPN6011014444; ＰＥＴＩＳＩ，Ｊ．　ｅｔ　ａｌ．: '６-Ｄｅｏｘｙｔｅｔｒａｃｙｃｌｉｎｅｓ．　ＩＩ．　Ｎｉｔｒａｔｉｏｎｓ　ａｎｄ　ｓｕｂｓｅｑｕｅｎｔ　ｒｅａｃｔｉｏｎｓ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．５, 1962, ｐ．５３８-５４６
JPN6011014445; ＨＬＡＶＫＡ，Ｊ．Ｊ．　ｅｔ　ａｌ．: 'Ｔｈｅ　６-ｄｅｏｘｙｔｅｔｒａｃｙｃｌｉｎｅｓ．　ＩＩＩ．　Ｅｌｅｃｔｒｏｐｈｉｌｉｃ　ａｎｄ　ｎｕｃｌｅｏｐｈｉｌｉｃ　ｓｕｂｓｔｉｔｕｔｉｏｎ' Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｃｈｅｍｉｃａｌ　ＳｏｃｉｅｔｙＶｏｌ．８４, 1962, ｐ．１４２６-１４３０
JPN6011014443; ＢＡＲＤＥＮ，Ｔ．Ｃ．　ｅｔ　ａｌ．: '"Ｇｌｙｃｙｌｃｙｃｌｉｎｅｓ"．　３．　９-Ａｍｉｎｏｄｏｘｙｃｙｃｌｉｎｅｃａｒｂｏｘａｍｉｄｅｓ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．３７，　Ｎｏ．２０, 1994, ｐ．３２０５-３２１１
JPN6011014444; ＰＥＴＩＳＩ，Ｊ．　ｅｔ　ａｌ．: '６-Ｄｅｏｘｙｔｅｔｒａｃｙｃｌｉｎｅｓ．　ＩＩ．　Ｎｉｔｒａｔｉｏｎｓ　ａｎｄ　ｓｕｂｓｅｑｕｅｎｔ　ｒｅａｃｔｉｏｎｓ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．５, 1962, ｐ．５３８-５４６
JPN6011014445; ＨＬＡＶＫＡ，Ｊ．Ｊ．　ｅｔ　ａｌ．: 'Ｔｈｅ　６-ｄｅｏｘｙｔｅｔｒａｃｙｃｌｉｎｅｓ．　ＩＩＩ．　Ｅｌｅｃｔｒｏｐｈｉｌｉｃ　ａｎｄ　ｎｕｃｌｅｏｐｈｉｌｉｃ　ｓｕｂｓｔｉｔｕｔｉｏｎ' Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｃｈｅｍｉｃａｌ　ＳｏｃｉｅｔｙＶｏｌ．８４, 1962, ｐ．１４２６-１４３０

Attorney, Agent or Firm:

Hatsushi Shimizu
Kazunori Hashimoto

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