Title:
β-ラクタマーゼ阻害剤としての7-アルキリデン-3-置換型-3-セフェム-4-カルボキシラート
Document Type and Number:
Japanese Patent JP2005502687
Kind Code:
A
Abstract:
The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting beta-lactamase enzymes, for enhancing the activity of beta-lactam antibiotics, and for treating beta-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula (I), and intermediates useful for the synthesis of compounds of formula (I).
Inventors:
Binaku, John, Dee
Vogueti, Lakshmi Narayana
Vogueti, Lakshmi Narayana
Application Number:
JP2003525002A
Publication Date:
January 27, 2005
Filing Date:
July 24, 2002
Export Citation:
Assignee:
ALAMX,L.L.C.
International Classes:
A61K31/43; A61K31/431; A61K31/545; A61K31/546; A61P31/04; A61P43/00; C07D501/00; C07D501/14; (IPC1-7): C07D501/00; A61K31/43; A61K31/431; A61K31/545; A61K31/546; A61P31/04; A61P43/00
Attorney, Agent or Firm:
Mitsuo Tanaka
Masaki Yano
Masaki Yano