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Title:
7ABETA-METHYL-2,3,3AALPHA,4,5,6,7,7A-OCTAHYDRO-1H-INDENE-1,5-DIONE-4ALPHA-(3-PROPIONIC ACID)-PIVALIC ACID MIXED ANHYDRIDE
Document Type and Number:
Japanese Patent JPS6425747
Kind Code:
A
Abstract:

NEW MATERIAL: A compd. expressed by a formula I.

USE: An intermediate for steroid synthesis.

PROCESS: A compd. expressed by a formula I is obtained by treating a bicylic diketopropionic acid expressed by a formula II with pivaloyl chloride in the presence of triethylamine preferably. Then triketoketal expressed by formula IV is obtained by treating the compd. expressed by the formula I with a Grignard reagent expressed by a formula III (X is Cl and Br), then a ricyclic compd. expressed by a formula V is obtained by cyclizing the triketoketal in the presence of a base. The compd. expressed by the formula V can be easily converted to an already known useful steroid compd. such as NAD.


Inventors:
GARI EFU KUUPAA
ARUBAATO AARU BUAN HOON
Application Number:
JP14594388A
Publication Date:
January 27, 1989
Filing Date:
June 15, 1988
Export Citation:
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Assignee:
SYNTEX INC
International Classes:
A61K31/585; C07C69/716; C07C49/597; C07C49/613; C07C51/56; C07C59/205; C07C59/82; C07D317/26; C07J1/00; C07J17/00; (IPC1-7): C07C69/716
Attorney, Agent or Firm:
Aoki Akira (3 outside)