NEW MATERIAL:The compound of formula I (R is H or OCH3).
USE: An intermediate of 4-demethyoxyfeudomycinone or feudomycinone useful as a carcinostatic agent.
PREPARATION: The compound of formula I can be prepared by adding an allylation agent to the compound of formula II. The obtained compound can be converted to the above carcinostatic agent by the conventional method such as Wacker oxidation, protection of ketone, bromination at the 10-position, and alkali treatment, etc. The starting compound of formula II can be prepared by oxidizing quinizarin or 1,4,5-trimethyoxy-9,10-anthraquinone, carrying out the Diels-Adler addition reaction of the resultant anthracene (or 5-methoxyanthracene)-1,4,9,10-tetraone with 2-acetoxy-1,3-butadiene, and hydrolyzing the product.
KUSANO YUKARI
SAWAHATA YOSHIKAZU
