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Title:
9-AMINOTETRAHYDROACRIDINES AND RELATED COMPOUND
Document Type and Number:
Japanese Patent JPH04312578
Kind Code:
A
Abstract:

PURPOSE: To provide a novel compd. which has memory function disorder lessening activity and is useful as a therapeutic agent for Alzheimer's disease.

CONSTITUTION: The compd. of formula I {Y is C=O, CHOH; R1 is H, lower alkyl; R2 is H, lower alkyl, phenyl, lower alkyl; R3 is H, OR4 [R4 is H, COR5 (R5H is lower alkyl)] X is H, lower alkyl, halogen, lower alkoxy, hydroxy, trifluoromethyl}. For example, 9-methylamino-1,2,3,4-tetrahydro-1,4-acridinediol. The compd. of the formula I is obtd. by subjecting the compd. of formula II to reduction oxidation by hydrogenation in the presence of a catalyst, such as platinum-carbon, under an acidic condition in an ether based solvent, such as THF.


Inventors:
Shutske, Gregory Michael
Kapples, Kevin James
Tomer, John Dick
Application Number:
JP1992000024914
Publication Date:
November 04, 1992
Filing Date:
February 12, 1992
Export Citation:
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Assignee:
HOECHST ROUSSEL PHARMACEUT INC
International Classes:
A61K31/435; A61K31/47; A61K31/473; A61P25/28; C07D219/04; C07D219/06; C07D219/10; C07D261/20; C07F7/08; C07F7/10; C07F7/12; C07D; (IPC1-7): A61K31/435; C07D219/10; C07D261/20
Domestic Patent References:
1986-07-05
1992-08-11



 
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