Title:
9,10-セコプレグナン誘導体及び医薬
Document Type and Number:
Japanese Patent JP5176956
Kind Code:
B2
Abstract:
A main object of the invention is to provide a novel useful vitamin D 3 derivative, which has an excellent vitamin D 3 activity and, as compared with conventional vitamin D 3 derivatives, has a relatively small amount of influence on the systemic calcium metabolism. The invention includes a 9,10-secopregnane derivative of the following general formula [1] and a pharmaceutical composition containing it as active ingredient.
In the general formula [1], the following partial structure between the 16-position and the 17-position means a single bond or a double bond:
Y is a single bond, an alkylene, an alkenylene or phenylene; R 1 and R 2 are the same or different, each represents hydrogen, an alkyl or a cycloalkyl; or R 1 and R 2 , taken together with the adjacent carbon atom, form a cycloalkyl; R 3 is hydrogen or methyl; Z is hydrogen, hydroxy or -NR 11 R 12 .
Inventors:
Hiroki Fujieda
Hironori Otsu
Shoji Anfuku
Shirai Masaaki
Hironori Otsu
Shoji Anfuku
Shirai Masaaki
Application Number:
JP2008520547A
Publication Date:
April 03, 2013
Filing Date:
June 01, 2007
Export Citation:
Assignee:
NIPPON SHINYAKU CO.,LTD.
International Classes:
C07C401/00; A61K31/59; A61P17/06
Domestic Patent References:
| JPH10502940A | 1998-03-17 | |||
| JPH10231284A | 1998-09-02 | |||
| JPH08509971A | 1996-10-22 | |||
| JPH10502940A | 1998-03-17 |
Foreign References:
| WO2001096293A1 | 2001-12-20 | |||
| WO2001096293A1 | 2001-12-20 |
Attorney, Agent or Firm:
Naoto Shimizu