Title:
9,11エポキシステロイドの改良型製造方法
Document Type and Number:
Japanese Patent JP2007530557
Kind Code:
A
Abstract:
Processes are described for epoxidation reactions. In particular, the process comprises the conversion of a steroid substrate having an olefinic unsaturation in the steroid nucleus to a structure comprising a 9,11-epoxy substituent by reaction of the substrate with a peroxide compound in the presence of a peroxide activator. The epoxidation processes described are conducted at relatively low hydrogen peroxide to steroid substrate ratio. Several optional process modifications are described.
Inventors:
Bixolek, Joseph Jay.
Meist, Keith Dee.
David, Paul
Carlos, Marlon Buoy.
Kim, Chun Si.
Meist, Keith Dee.
David, Paul
Carlos, Marlon Buoy.
Kim, Chun Si.
Application Number:
JP2007505072A
Publication Date:
November 01, 2007
Filing Date:
March 22, 2005
Export Citation:
Assignee:
Pharmacia & Up John Company LRC
International Classes:
C07J71/00; C07J21/00; C07J75/00; C07B53/00
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura