Title:
99CISS6*6**DIAPOOPSI*PSIICAROTIN DIACID DERIVATIVE* ITS MANUFACTURE AND MEDICINAL COMPOSITION CONTAINING IT
Document Type and Number:
Japanese Patent JPS56103147
Kind Code:
A
Abstract:
The invention provides new derivatives of the 9-cis-66 min -diapo- PSI PSI -carotenedioic acid of general formula wherein R is a radical selected from the group comprising (wherein n=0,1,2 and x, y, the same of different are H, halogen, alkoxy, hydroxy, alkyl or trifluoromethyl radical); 2,3-pyridyl; 4-pyridyl; 2,3-pyridyl-methyl; 3-pyridyl-methyl. The compounds of the formula (I) can be prepared from the corresponding acid by directly reacting an amine of the formula R-NH2 (wherein R has the proviously specified meanings) in an aprotic solvent in the presence of an activator for the carboxylic group, or by previously transforming the above mentioned acid into the corresponding acid chloride or into the corresponding mixed anhydride and then carrying out the reaction with the amine R-NH2. The compounds of formula (I) are used in pharmaceutical compositions useful in the therapeutic prevention of diseases.
Inventors:
GIORUJIO FUERARI
BITSUTORIO BEKUCHIETEI
BITSUTORIO BEKUCHIETEI
Application Number:
JP16945480A
Publication Date:
August 18, 1981
Filing Date:
December 01, 1980
Export Citation:
Assignee:
SIMES
International Classes:
A61K31/225; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/22; A61K31/4418; A61P35/02; C07C233/09; C07C233/13; C07C233/15; C07C233/20; C07C233/27; C07D213/40; C07D213/75; (IPC1-7): A61K31/22; A61K31/44; C07C103/58; C07D213/40; C07D213/75