Title:
A3アデノシンレセプタ・アロステリックモジュレータ
Document Type and Number:
Japanese Patent JP5414277
Kind Code:
B2
Abstract:
The claimed subject matter relates to allosteric modulation of A3 adenosine receptor (A3AR) and provides for the use of an A3 adenosine receptor modulator (A3RM), for the preparation of pharmaceutical compositions for modulating the A3AR in a subject, as well as pharmaceutical compositions including the same and therapeutic methods including administering to a subject an amount of an A3RM, the amount being effective to modulate A3AR activity. The A3RM according to claimed subject matter are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives. Also provided are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives.
Inventors:
Anico Goblioth
Johannes Brusse
Adrien P. Itzeherman
Tsang-Guo Gao
Kenneth Jacobson
Johannes Brusse
Adrien P. Itzeherman
Tsang-Guo Gao
Kenneth Jacobson
Application Number:
JP2008552392A
Publication Date:
February 12, 2014
Filing Date:
January 25, 2007
Export Citation:
Assignee:
The Government of the United States of America Represented by the Secretary Department of Health and Human Services
Universeit Reiden
Universeit Reiden
International Classes:
A61K31/4745; A61P9/10; A61P17/00; A61P19/02; A61P29/00; A61P35/00; A61P43/00; C07D471/04; A61P1/04; A61P9/04; A61P17/06; A61P25/00; A61P27/02; A61P27/06; A61P37/02
Domestic Patent References:
| JP2002516910A |
Foreign References:
| WO2002062801A1 |
Other References:
Molecular Pharmacology,2002年,Vol.62,pp.81-89
Journal of Medicinal Chemistry,1991年,Vol.34,pp.1202-1206
Journal of Medicinal Chemistry,1991年,Vol.34,pp.1202-1206
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro