Title:
ANTIBODY CONTAINING IgG2 HAVING AMINO ACID MUTATION INTRODUCED THEREIN
Document Type and Number:
Japanese Patent JP2015146805
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a monoclonal antibody having an agonistic activity and binding to human CD40, a DNA encoding the monoclonal antibody, a vector comprising the DNA, a transformant obtained by introducing the vector, a method for producing the monoclonal antibody using the transformant, a pharmaceutical composition comprising the monoclonal antibody, and a therapeutic agent.SOLUTION: The invention relates to a monoclonal antibody having a specific amino acid sequence which has an agonistic activity and binds to human CD40. In the amino acid sequence, the monoclonal antibody has a heavy chain constant region which is IgG2 in which at least the valine at position 234 is substituted by an alanine, the glycine at position 237 is substituted by an alanine, and the proline at position 331 is substituted by a serine (as numbered according to the EU index as in Kabat et al.).
Inventors:
MATSUSHIMA AKI
NAMISAKI HIROSHI
YAGI SHIGENORI
NAMISAKI HIROSHI
YAGI SHIGENORI
Application Number:
JP2015021137A
Publication Date:
August 20, 2015
Filing Date:
February 05, 2015
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD
International Classes:
C12N15/09; A61K39/395; A61P31/00; A61P35/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| JP5694921B2 | 2015-04-01 | |||
| JP2007525171A | 2007-09-06 | |||
| JP2005508176A | 2005-03-31 |
Foreign References:
| WO2005063981A1 | 2005-07-14 |
Other References:
COLE, M.S., ET AL., J. IMMUNOL., vol. 159, no. 7, JPN6010031619, 1997, pages 3613 - 3621, ISSN: 0003389840
KIMURA, K., ET AL., AM. J. PATHOL., vol. 168, no. 3, JPN6010031620, March 2006 (2006-03-01), pages 786 - 795, ISSN: 0003389841
KIMURA, K., ET AL., AM. J. PATHOL., vol. 168, no. 3, JPN6010031620, March 2006 (2006-03-01), pages 786 - 795, ISSN: 0003389841
Attorney, Agent or Firm:
Patent business corporation glory patent office