Title:
ＡＳＫ１阻害ピロロピリミジン及びピロロピリジン誘導体
Document Type and Number:
Japanese Patent JP7198263
Kind Code:
B2
Abstract:
The present invention relates to pyrrolopyrimidine compounds according to Formula I and their use in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. In a particular aspect, the present compounds are ASK inhibitors, particularly ASK1 inhibitors. The present invention also provides methods for the production of a compound of the invention, pharmaceutical compositions comprising a compound of the invention, the use of the compounds in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases.
Inventors:
David Amantini
milan mesh
Gordon Saxty
Tanja Poljak
Ines Brjasnovik
Dinko Jihel
David Whitty
carl richard gibson
milan mesh
Gordon Saxty
Tanja Poljak
Ines Brjasnovik
Dinko Jihel
David Whitty
carl richard gibson
Application Number:
JP2020501447A
Publication Date:
December 28, 2022
Filing Date:
July 12, 2018
Export Citation:
Assignee:
Galapagos N.V.
International Classes:
C07D471/04; A61K31/4545; A61K31/519; A61P3/10; A61P9/00; A61P25/00; A61P25/04; A61P29/00; A61P35/00; A61P43/00; C07D487/04
Domestic Patent References:
| JP2014505037A | ||||
| JP2012532931A |
Attorney, Agent or Firm:
Toru Ishikawa