Title:
AAV VIRION WITH DECREASED IMMUNOREACTIVITY AND USE THEREOF
Document Type and Number:
Japanese Patent JP2016084362
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide an AAV variant with decreased immunoreactivity.SOLUTION: There are disclosed a method for preparing recombinant AAV virion with decreased immunoreactivity and a method for using the same. The recombinant AAV virion includes mutated capsid proteins or is derived from non-primate mammalian AAV serotypes and isolates that display decreased immunoreactivity against AAV-2. There are provided, in one embodiment, a method for effective delivery of a heterologous nucleic acid molecule (HNA) to cells or tissues of a vertebrate subject (for example, a mammalian) using the recombinant AAV virion, and an AAV vector used in the method.SELECTED DRAWING: Figure 1
Inventors:
ARBETMAN ALEJANDRA ELENA
COLOSI PETER
LOCHRIE MICHAEL A
SUROSKY RICHARD T
COLOSI PETER
LOCHRIE MICHAEL A
SUROSKY RICHARD T
Application Number:
JP2016019562A
Publication Date:
May 19, 2016
Filing Date:
February 04, 2016
Export Citation:
Assignee:
GENZYME CORP
International Classes:
C07K14/015; A61K31/7088; A61K31/7105; A61K35/761; A61K38/36; A61K48/00; C07K1/00; C07K14/00; C07K17/00; C12N7/04; C12N15/00; C12N15/09; C12N15/63; C12N15/70; C12N15/74; A61K
Attorney, Agent or Firm:
Takeshi Oshio