Title:
ABUSE-RESISTANT OPIOID DOSAGE FORM
Document Type and Number:
Japanese Patent JP2013053165
Kind Code:
A
Abstract:
To provide a pharmaceutical dosage form comprising an opioid agonist and one or more opioid antagonists contained in a matrix separate from the opioid agonist.
The separate matrix for the opioid antagonist allows independent release rates to be achieved for the opioid and opioid antagonist(s). The antagonist(s) can be released slowly or fully contained when the tablet is taken orally. Crushing the tablet allows full release of the antagonist(s), deterring abuse. The abuse deterring antagonist(s) may be an opioid antagonist, an irritant, another appropriate antagonist(s), or a combination thereof. The invention also allows variable release of the opioid and antagonist(s).
Inventors:
KAO HUAI-HUNG
ZENG YADI
HOWARD-SPARKS MICHELLE
JIM FAI
ZENG YADI
HOWARD-SPARKS MICHELLE
JIM FAI
Application Number:
JP2012276500A
Publication Date:
March 21, 2013
Filing Date:
December 19, 2012
Export Citation:
Assignee:
ENDO PHARMACEUTICALS INC
International Classes:
A61K9/26; A61K9/28; A61K9/24; A61K31/485; A61K45/06; A61K47/32; A61K47/38; A61P25/36; A61P43/00; A61K9/16; A61K9/20
Domestic Patent References:
| JPH10507740A | 1998-07-28 | |||
| JPH09504267A | 1997-04-28 | |||
| JP2001526229A | 2001-12-18 | |||
| JP2002544160A | 2002-12-24 |
Foreign References:
| WO1999032120A1 | 1999-07-01 | |||
| WO2000067739A2 | 2000-11-16 | |||
| WO1999011250A2 | 1999-03-11 | |||
| US4457933A | 1984-07-03 | |||
| US3773955A | 1973-11-20 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita