Title:
アセチル2-ヒドロオキシ-1,3-ダイアミノアルカン
Document Type and Number:
Japanese Patent JP2006504793
Kind Code:
A
Abstract:
Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
Inventors:
Maillard, Michelle
Baldwin, Eric, Tee.
Beck, James, Pee.
Hughes, Robert
John, Verghese
Pree, Shion, Earl.
Templink, loose
Baldwin, Eric, Tee.
Beck, James, Pee.
Hughes, Robert
John, Verghese
Pree, Shion, Earl.
Templink, loose
Application Number:
JP2004571986A
Publication Date:
February 09, 2006
Filing Date:
September 10, 2003
Export Citation:
Assignee:
PHARMACIA & UPJOHN COMPANY
Pharmacia & Up John Company LRC
Pharmacia & Up John Company LRC
International Classes:
C07C233/36; A61K31/135; A61K31/16; A61K31/165; A61K31/18; A61K31/341; A61K31/35; A61K31/353; A61K31/38; A61K31/381; A61K31/382; A61K31/40; A61K31/4025; A61K31/4045; A61K31/4164; A61K31/4196; A61K31/42; A61K31/426; A61K31/44; A61K31/4409; A61K31/4433; A61K31/4706; A61K31/50; A61K31/505; A61K31/5375; A61P25/16; A61P25/28; C07C233/05; C07C235/10; C07C235/74; C07C271/24; C07C311/05; C07C327/30; C07D209/14; C07D213/36; C07D213/38; C07D215/233; C07D215/38; C07D215/42; C07D215/46; C07D233/61; C07D237/14; C07D239/26; C07D249/08; C07D261/08; C07D265/30; C07D277/28; C07D307/52; C07D311/04; C07D311/68; C07D311/74; C07D311/76; C07D333/20; C07D335/04; C07D335/06; C07D405/04; C07D495/04; C07D215/22
Domestic Patent References:
| JP2001510474A | 2001-07-31 | |||
| JP2004535421A | 2004-11-25 | |||
| JP2005511735A | 2005-04-28 | |||
| JPS61118352A | 1986-06-05 | |||
| JPH08501299A | 1996-02-13 | |||
| JP2005504737A | 2005-02-17 | |||
| JP2005520791A | 2005-07-14 | |||
| JP2005538162A | 2005-12-15 |
Foreign References:
| WO2002002518A2 | 2002-01-10 | |||
| WO2002002520A2 | 2002-01-10 | |||
| WO2002002512A2 | 2002-01-10 | |||
| US5968942A | 1999-10-19 | |||
| WO1999006369A1 | 1999-02-11 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda