Title:
アセチレン誘導体、ならびにアミロイドプラークと結合し、および画像化するためのそれらの使用
Document Type and Number:
Japanese Patent JP2010512325
Kind Code:
A
Abstract:
The invention relates to radiolabeled compounds and their use in methods of imaging amyloid deposits, as well as to methods of their manufacture. The invention also relates to compounds for inhibiting the aggregation of amyloid proteins that form amyloid deposits, methods for delivering therapeutic agents to amyloid deposits, as well as methods of making compounds that inhibit the aggregation of amyloid proteins.
Inventors:
Kung, Hank F.
Kung, mapping
Kung, mapping
Application Number:
JP2009540328A
Publication Date:
April 22, 2010
Filing Date:
December 07, 2007
Export Citation:
Assignee:
The Trustees of the University of Pennsylvania
International Classes:
C07C15/54; A61K31/05; A61K31/136; A61K31/44; A61K51/00; A61P25/28; A61P43/00; C07C43/23; C07C205/35; C07C211/50; C07C211/52; C07C215/16; C07C215/74; C07C217/80; C07D213/64; C07D213/74
Domestic Patent References:
| JP2004505998A | 2004-02-26 | |||
| JP2006077239A | 2006-03-23 | |||
| JP2001089407A | 2001-04-03 | |||
| JP2005518352A | 2005-06-23 | |||
| JP2006089485A | 2006-04-06 | |||
| JPH0812599A | 1996-01-16 | |||
| JPH07324045A | 1995-12-12 | |||
| JPH04234828A | 1992-08-24 | |||
| JP2006513996A | 2006-04-27 |
Foreign References:
| WO2005094822A1 | 2005-10-13 | |||
| WO2006115895A2 | 2006-11-02 | |||
| US20040023479A1 | 2004-02-05 | |||
| US20060235037A1 | 2006-10-19 | |||
| US20050020838A1 | 2005-01-27 | |||
| CN1434331A | 2003-08-06 |
Other References:
JPN5010009076; ＱＵ: ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖ１７ Ｎ１３, 20070701, Ｐ３５８１-３５８４
JPN6013013521; Ｓｐａｄｌｏ， Ａｎｎａ ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ， ｍｅｓｏｍｏｒｐｈｉｃ ａｎｄ ｏｐｔｉｃａｌ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ｉｓｏｔｈｉｏｃｙａｎａｔｏｔｏｌａｎｅｓ' Ｌｉｑｕｉｄ Ｃｒｙｓｔａｌｓ ３０（２）, 2003, １９１-１９８
JPN6013013522; Ｍａｔｈｅｗｓ， Ｗｉｌｌｉａｍ Ｂ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ａ ｍＧｌｕＲ５ ａｎｔａｇｏｎｉｓｔ ｕｓｉｎｇ ［１１Ｃ］ｃｏｐｐｅｒ（Ｉ） ｃｙａｎｉｄｅ' Ｊｏｕｒｎａｌ ｏｆ Ｌａｂｅｌｌｅｄ Ｃｏｍｐｏｕｎｄｓ ａｎｄ Ｒａｄｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ ４９（９）, 2006, ８２９-８３４
JPN6013013521; Ｓｐａｄｌｏ， Ａｎｎａ ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ， ｍｅｓｏｍｏｒｐｈｉｃ ａｎｄ ｏｐｔｉｃａｌ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ｉｓｏｔｈｉｏｃｙａｎａｔｏｔｏｌａｎｅｓ' Ｌｉｑｕｉｄ Ｃｒｙｓｔａｌｓ ３０（２）, 2003, １９１-１９８
JPN6013013522; Ｍａｔｈｅｗｓ， Ｗｉｌｌｉａｍ Ｂ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ａ ｍＧｌｕＲ５ ａｎｔａｇｏｎｉｓｔ ｕｓｉｎｇ ［１１Ｃ］ｃｏｐｐｅｒ（Ｉ） ｃｙａｎｉｄｅ' Ｊｏｕｒｎａｌ ｏｆ Ｌａｂｅｌｌｅｄ Ｃｏｍｐｏｕｎｄｓ ａｎｄ Ｒａｄｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ ４９（９）, 2006, ８２９-８３４
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Masaru Nakajima